The prognostic significance of circulating plasma cells in newly diagnosed multiple myeloma patients

Objective Multiple myeloma (MM) is a highly characteristic tumor that influenced by numerous factors determine its prognosis. Studies indicate the presence of circulating plasma cells (cPCs) detrimental factor significantly impacts prognosis patients with MM. Methods This study retrospectively analyzed prognostic value cPCs quantified 10-color flow cytometry in 145 newly diagnosed MM (NDMM) cases First Affiliated Hospital Soochow University from November 2018 to February 2021. The was approved Ethics Committee hospital (2021 No. 93). Results Of patients, 99 (68.2%) were detected cPCs. Through receiver operating characteristics (ROC) analysis, an optimal threshold 0.165% identified as predictor for overall survival (OS). median progression-free (PFS) 33 months ≥0.165%, whereas those <0.165% had PFS <33 (p=0.001). OS not reached two groups; 3-year ≥0.165% 71% compared 87% (p=0.003). In transplant also predicted worse Similarly, when considering cytogenetic risk conjunction cPC levels, comparable results obtained. To evaluate whether Revised International Staging System (R-ISS) groups could be further stratified based on different related cPCs, our revealed similar and rates R-ISS II stage III (p=0.659 0.249, respectively). Conclusion demonstrates high ratio serves reliable indicator predicting poorer cases. Furthermore, incorporating system alongside level enhances accuracy predictions